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Product Description
LIGHT belongs to the TNF family of ligands, and can signal through the herpes virus entry mediator type A receptor (HVEM, TNFRSF14), LTR, or bind to a decoy receptor, DcR3. It is expressed in splenocytes, activated PBL, CD+8 tumor infiltrating lymphocytes, granulocytes, and monocytes. LIGHT has the ability to active NFB, to co-stimulate the activation of lymphocytes and to induce apoptosis in certain human tumor cells. Recombinant murine LIGHT is a 20.1 kDa protein containing 183 amino acid residues.
Biovision | P1292 | LIGHT Murine Recombinant DataSheet
Biomolecule/Target: LIGHT
Synonyms: TNFSF14, HVEM-L, Tumor necrosis factor ligand superfamily member 14, Herpes virus entry mediator ligand, Herpesvirus entry mediator ligand, CD258, LIGHT
Alternates names: MCGF (Mast cell growth factor), Multi-CSF, HCGF, P-cell stimulation factor, IL-3, MGC79398, MGC79399.
Taglines: Apoptosis inducer
NCBI Gene ID #: 3562
NCBI Gene Symbol: IL3
Gene Source: Human
Accession #: P08700
Recombinant: Yes
Source: Human 293 cell expressed
Purity by SDS-PAGEs: 95%
Assay: SDS-PAGE
Purity: N/A
Assay #2: N/A
Endotoxin Level: <0.1 EU/g
Activity (Specifications/test method): N/A
Biological activity: ED is typically 0.5 to 2 ng/mL.The activity was determined by the dose dependent stimulation of the proliferation of human TF-1 cells (human erythroleukemic indicator cell line).
Results: 0.5 to 2 ng/ml
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: 17 to 45 kDa, monomer, glycosylated
Concentration: N/A
Appearance: Lyophilized
Physical form description: Lyophilized from 20mM Tris, pH 8.5 + 100 mM Arginine.
Reconstitution Instructions: Reconstitute in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin.
Amino acid sequence: N/A
