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Product Description
MDC is a CC chemokine that is produced in B cells, macrophages, monocyte-derived dendritic cells, activated NK cells and CD4 T cells. It signals through the CCR4 receptor. MDC chemoattracts monocytes, dendritic cells and NK cells and exerts HIV suppressive activity. The 67 amino acid form of MDC displays reduced chemoattractant activity but retains HIV suppressive activity. Recombinant murine MDC is a 7.8 kDa protein containing 68 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines.
Biovision | 7169 | MDC/CCL22 murine recombinant DataSheet
Biomolecule/Target: CCL22
Synonyms: Macrophage-Derived Chemokine, CCL22, STCP-1, ABCD-1
Alternates names: Kit ligand Precursor, C-kit ligand, SCF, Mast cell growth factor, MGF, SF, KL-1, Kit l, DKFZp686F2250.
Taglines: Chemoattracts monocytes, dendritic cells and NK cells
NCBI Gene ID #: 4254
NCBI Gene Symbol: KITLG
Gene Source: Human
Accession #: P21583
Recombinant: Yes
Source: Human 293 cell expressed
Purity by SDS-PAGEs: > 95%
Assay: SDS-PAGE
Purity: N/A
Assay #2: HPLC
Endotoxin Level: < 1.0 EU per 1 g of protein
Activity (Specifications/test method): N/A
Biological activity: ED is typically 5 to 25 ng/mL. The specific activity was determined by the dose-dependent stimulation of the proliferation of human TF-1 cells (human erythroleukemic indicator cell line).
Results: 5 to 25 ng/ml
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: 35 to 45 kDa, monomer, glycosylated
Concentration: N/A
Appearance: Lyophilized powder
Physical form description: Sterile filtered through a 0.2 micron filter. Lyophilized with no additives.
Reconstitution Instructions: Reconstitute in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin.
Amino acid sequence: N/A
