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Product Description
MEC is a secreted CC chemokine expressed primarily by epithelial cells of the bronchioles, salivary gland, mammary gland and colon. MEC signals through the CCR10 receptor and chemoattracts resting CD4, CD8 T cells and eosinophils. MEC contains six cysteines including the four highly conserved cysteine residues present in CC chemokines. Recombinant human MEC is a 12.3 kDa protein containing 108 amino acid residues.
Biovision | 7170 | MEC/CCL28 human recombinant DataSheet
Biomolecule/Target: CCL28
Synonyms: Mucosae-associated Epithelial Chemokine, CCL28, CCK-1
Alternates names: Transforming growth factor beta-1, TGF-beta-1, CED, DPD1, TGFB, TGF-b 1, LAP, TGFB1.
Taglines: Chemoattracts resting CD4, CD8 T cells and eosinophils
NCBI Gene ID #: 7040
NCBI Gene Symbol: TGFB1
Gene Source: Human
Accession #: P01137
Recombinant: Yes
Source: Human 293 cell expressed
Purity by SDS-PAGEs: > 95%
Assay: SDS-PAGE
Purity: N/A
Assay #2: HPLC
Endotoxin Level: < 1.0 EU per 1 g of protein
Activity (Specifications/test method): N/A
Biological activity: ED is typically 0.1 to 0.5 ng/mL. The specific activity was determined by the dose-dependent inhibition of IL-4 induced proliferation of mouse HT-2 cells (BALB/c spleen activated by sheep erythrocytes in the presence of IL-2).
Results: 0.1 to 0.5 ng/ml
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: 25 kDa, homodimer, nonglycosylated
Concentration: N/A
Appearance: Lyophilized powder
Physical form description: Sterile filtered through a 0.2 micron filter. Lyophilized from 10 mM Acetic Acid.
Reconstitution Instructions: Reconstitute in sterile 4 mM HCl containing 0.1% endotoxin-free recombinant human serum albumin.
Amino acid sequence: N/A
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