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Product Description
The cytokine Macrophage migration inhibitory factor (MIF) has been identified to be secreted by the pituitary gland and the monocyte/macrophage and to play an important role in endotoxic shock. MIF has the unique property of being released from macrophages and T cells in response to physiological concentrations of glucocorticoids. The secretion of MIF is tightly regulated and decreases at high, anti-inflammatory steroid concentration. Recombinant human MIF is a single, non-glycosylated, polypeptide chain containing 115 amino acids and having a molecular mass of 12.5 kDa.
Biovision | 4984 | MIF human recombinant DataSheet
Biomolecule/Target: N/A
Synonyms: Phenylpyruvate tautomerase, Glycosylation-inhibiting factor, GIF, MMIF, MIF.
Alternates names: Megakaryocyte colony-stimulating factor, Myeloproliferative leukemia virus oncogene ligand, C-mpl ligand, ML, Megakaryocyte growth and development factor, MGDF, TPO, MKCSF, MPLLG, MGC163194, THPO.
Taglines: A protein which triggesr an acute immune response
NCBI Gene ID #: 7066
NCBI Gene Symbol: THPO
Gene Source: Human
Accession #: P40225
Recombinant: Yes
Source: Human 293 cell expressed
Purity by SDS-PAGEs: > 95%
Assay: SDS-PAGE
Purity: 97%
Assay #2: HPLC
Endotoxin Level: < 1.0 EU per 1 g of protein
Activity (Specifications/test method): N/A
Biological activity: ED is typically 0.5 to 5 ng/mL. The specific activity was determined by the dose-dependent stimulation of the proliferation of human M07e cells
Results: 0.5 to 5 ng/ml
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: 80 to 85 kDa, monomer, glycosylated
Concentration: N/A
Appearance: Lyophilized protein
Physical form description: MIF-Protein was lyophilized from 10 mM sodium phosphate buffer pH-7.5.
Reconstitution Instructions: Reconstitute in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin.
Amino acid sequence: N/A
