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Product Description
Both MIP-1 and MIP-1 are structurally and functionally related CC chemokines. They participate in the host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells e.g. macrophages, lymphocytes and NK cells. While both MIP-1 and MIP-1 exert similar effects on monocytes their effect on lymphocytes differ; with MIP-1 selectively attracting CD8+ lymphocytes and MIP-1 selectively attracting CD4+ lymphocytes. Additionally, MIP-1 and MIP-1 have also been shown to be potent chemo attractants for B cells, eosinophils and dendritic cells. Both human and murine MIP-1 and MIP-1 are active on human and murine hematopoietic cells. Recombinant human MIP-1 is a 7.8 kDa protein containing 70 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.
Biovision | 7173 | MIP-1/CCL3 human recombinant DataSheet
Biomolecule/Target: CCL3
Synonyms: Macrophage Inflammatory Protein-1, CCL3, LD78
Alternates names:
Taglines: Participates in the host response to invading bacterial, viral, parasite and fungal pathogens
NCBI Gene ID #: 6233
NCBI Gene Symbol: RPS27A
Gene Source: Human
Accession #: P62979
Recombinant: Yes
Source: E. Coli
Purity by SDS-PAGEs: 95%
Assay: SDS-PAGE
Purity: N/A
Assay #2: HPLC
Endotoxin Level: N/A
Activity (Specifications/test method): N/A
Biological activity: N/A
Results: N/A
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: 8.760 kDa
Concentration: N/A
Appearance: Lyophilized powder
Physical form description: Sterile filtered through a 0.2 micron filter. Lyophilized with no additives.
Reconstitution Instructions: N/A
Amino acid sequence: N/A
