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Product Description
The Matrix metalloproteinase-14 (MMP-14) belongs to a family of zinc-dependent endopeptidases. The ability of MMP-14 to degrade type I collagen, and activate pro-MMP-2 and pro-MMP-9 makes it a key enzyme in many physiological and pathological processes such as angiogenesis and tumor invasion. MMP-14 is structurally a multi-domain metalloenzyme, composed of a prodomain, a metal-binding catalytic domain, a hinge region, a hemopexin-like domain, a transmembrane domain, and a cytoplamasic tail. The catalytic, and hinge domains of MT1-MMP were expressed in Escherichia coli and the active form was generated by successive autoproteolysis of the N- and C-terminal sites during refolding.
Biovision | 8009 | MMP-14 Active Human Recombinant DataSheet
Biomolecule/Target: MMP-14
Synonyms: Matrix metalloproteinase-14, MT1-MMP
Alternates names: Protein A
Taglines: >90% Pure, Active, Human Recombinant MMP-14
NCBI Gene ID #: 3919448
NCBI Gene Symbol: N/A
Gene Source: Staphylococcus aureus
Accession #: YP_498670
Recombinant: Yes
Source: E. coli
Purity by SDS-PAGEs: 97%
Assay: SDS-PAGE
Purity: N/A
Assay #2: HPLC
Endotoxin Level: <0.1 ng/g
Activity (Specifications/test method): N/A
Biological activity: N/A
Results: N/A
Binding Capacity: N/A
Unit Definition: One unit is defined as the amount of enzyme that hydrolyzes 1 µmol of Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 per min. at 37°C, pH 7.5.
Molecular Weight: 39.21 kDa
Concentration: N/A
Appearance: Lyophilized powder
Physical form description: Lyophilized from propriety buffer
Reconstitution Instructions: Reconstitute in HO
Amino acid sequence: N/A
