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Product Description
N-methylation is one method by which drug and other xenobiotic compounds are metabolized by the liver. NNMT is an important cytosolic methyltransferase catalyzing the N-methylation of nicotinamide, pyridines and structural analogs, playing a crucial role in the biotransformation and detoxification of many xenobiotic compounds. In the N-methylation process, NNMT uses S-adenosyl methionine as the methyl donor and nicotinamide as methyl acceptor. NNMT is mostly expressed in the liver, and a lower expression is seen in the kidney, lung, skeletal muscle, placenta and heart. It may also play an important role in regulating biological processes related to N-methyl nicotinamide such as anti-inflammatory, anti-thrombotic, vasoprotective, and gastroprotective properties. Increased NNMT activity was reported in many kinds of tumors. NNMT is a potential biomarker and therapeutic target in caner diagnosis and treatment. NNMT serum levels have significance in the premature detection and in the management of patients with colorectal cancer. The recombinant protein includes hNNMT with N-terminal His-tag.
Biovision | 7261 | Nicotinamide N-Methyltransferase Human Recombinant hNNMT DataSheet
Biomolecule/Target: NNMT
Synonyms: NNMT
Alternates names: Protein G
Taglines: A cytosolic methyltransferase catalyzing the N-methylation of nicotinamide
NCBI Gene ID #: N/A
NCBI Gene Symbol: N/A
Gene Source: Streptococcus sp
Accession #: CAA27638
Recombinant: Yes
Source: E. coli
Purity by SDS-PAGEs: 98%
Assay: SDS-PAGE
Purity: N/A
Assay #2: N/A
Endotoxin Level: <0.1 ng/g
Activity (Specifications/test method): N/A
Biological activity: N/A
Results: N/A
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: 26.1 kDa
Concentration: 3.42 mg/ml
Appearance: Liquid
Physical form description: 3.42 mg/ml solution in 25 mM Tris (pH8.0) buffer containing 20% glycerol
Reconstitution Instructions: Reconstitution in HO to a concentration of 5 mg/ml gives a clear solution.
Amino acid sequence: N/A
