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Product Description
Notch signaling pathway regulates many different cell fate decisions in both vertebrate and invertebrate species. There are 5 canonical Notch ligands in mammals: Jagged-1, Jagged-2, DLL1, DLL3 and DLL4. These can bind to the four Notch receptors Notch 1-4. It is important for pattern formation during development such as neurogenesis, angiogenesis or myogenesis and regulates T cell development and stem cell maintenance. Notch signaling is also involved in cellular processes through-out adulthood. Signaling via Notch occurs between neighbouring cells and both the receptor and its ligands are transmembrane proteins.
Biovision | 7531 | Notch-2 mouse recombinant DataSheet
Biomolecule/Target: Notch-2
Synonyms: Neurogenic Locus Notch Homolog Protein 2; Notch B
Alternates names: Neurogenic Locus Notch Homolog Protein 2; Notch B
Taglines: Protein involved in lateral inhibition in embryogenesis and multiple cellular processes through-out adulthood.
NCBI Gene ID #: 16181
NCBI Gene Symbol: IL-1RA
Gene Source: Mouse
Accession #: P25085
Recombinant: Yes
Source: CHO cells
Purity by SDS-PAGEs: 98%
Assay: SDS-PAGE
Purity: N/A
Assay #2: N/A
Endotoxin Level: <0.01 EU/g purified protein
Activity (Specifications/test method): N/A
Biological activity: The mouse IL-1Ra is capable of inhibiting IL-1-alpha activity in helper T cell line D10.G4.1.
Results: N/A
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: ~87.0 kDa. The extracellular domain of mouse Notch-2 (aa 26-494) (12 epidermal growth factor-like (EGF) repeats) is fused at the C-terminus to the Fc portion of human IgG1.
Concentration: N/A
Appearance: Lyophilized
Physical form description: Lyophilized with PBS
Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in sterile ddHO to a concentration 100 µg/ml. This solution can then be diluted into other aqueous buffers.
Amino acid sequence: The sequence of the first six N-terminal amino acids was determined and was found to be Ala-Cys-Arg-Pro-Ser-Gly.
