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Product Description
Protein C (PROC) is a vitamin K-dependent serine protease which regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. PROC is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form, which contains a serine protease domain, functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in the PROC gene are linked with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis. This protein is purified from fresh frozen human plasma using a combination of salt precipitations and column chromatography.
Biovision | 7682 | Protein C Human Plasma DataSheet
Biomolecule/Target: Protein C
Synonyms: Vitamin K-dependent protein C, Anticoagulant protein C, Autoprothrombin IIA, Blood coagulation factor XIV, PROC, PC, APC, PROC1, THPH3, THPH4.
Alternates names: Vitamin K-dependent protein C, Anticoagulant protein C, Autoprothrombin IIA, Blood coagulation factor XIV, PROC, PC, APC, PROC1, THPH3, THPH4.
Taglines: Regulates blood coagulation by inactivating factors Va and VIIIa
NCBI Gene ID #: 6352
NCBI Gene Symbol: TCP228
Gene Source: Human
Accession #: P13501
Recombinant: No
Source: Human Plasma
Purity by SDS-PAGEs: 98%
Assay: SDS-PAGE
Purity: N/A
Assay #2: N/A
Endotoxin Level: N/A
Activity (Specifications/test method): N/A
Biological activity: Determined by its ability to chemoattract human blood monocytes using a concentration range of 1-10 ng/ml.
Results: N/A
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: 62 kDa
Concentration: N/A
Appearance: Liquid
Physical form description: In 20 mM Tris-HCl, 0.1 M NaCl, 1 mM Benzamidine -pH 7.4
Reconstitution Instructions: Reconstitute in HO to a concentration of 0.1-1 µg/µl. This solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or 20°c for future use.
Amino acid sequence: N/A
