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Product Description
PTEN, a tumor suppressor, has been implicated in a large number of human tumors and is conserved from humans to worms. Characterization of PTEN protein showed that it is a phosphatase that acts on proteins and on 3-phosphorylated phosphoinositides, and can therefore modulate signal-transduction pathways that involve lipid second messengers. Recent results indicate that at least part of its role is to regulate the activity of the serine/threonine kinase AKT/PKB, and thus influence cell survival signaling. Recombinant PTEN is purified by proprietary chromatographic techniques.
Biovision | 4838 | PTEN human recombinant DataSheet
Biomolecule/Target: N/A
Synonyms: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, Phosphatase and tensin homolog, Mutated in Multiple advanced cancers 1, PTEN, MMAC1, TEP1, BZS, MHAM, PTEN1, 10q23del,
Alternates names: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, Phosphatase and tensin homolog, PTEN, MMAC1, TEP1, BZS, MHAM, PTEN1, 10q23del,
Taglines: A tumour supressor protein
NCBI Gene ID #: 81780
NCBI Gene Symbol: CCL5
Gene Source: Human
Accession #: P50231
Recombinant: Yes
Source: E. coli
Purity by SDS-PAGEs: 97%
Assay: SDS-PAGE
Purity: N/A
Assay #2: HPLC
Endotoxin Level: <0.1 ng/g
Activity (Specifications/test method): Not available at this time
Biological activity: Recombinant Rantes is fully biologically active when compared to standard. The activity is determined by the ability to chemoattract total human lymphocytes and murine T-cells at a concentration between 1-10 ng/ml.
Results: N/A
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: 80.0 kDa (GST tagged)
Concentration: 100 µg/ml
Appearance: Liquid
Physical form description: 100 µg/ml in 50 mM Tris-Acetate, pH 7.5, 150 mM NaCl, 0.1 mM EDTA, 10 mM glutathione, 25 mM DTT, 0.1 mM PMSF and 25% Glycerol.
Reconstitution Instructions: It is recommended to reconstitute the lyophilized product with sterile HO at a concentration of 0.1 mgs/ml, which can be further diluted into other aqueous solutions.
Amino acid sequence: N/A
