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Product Description
Sirtuin 6 (SIRT6) is a NAD-dependent protein deacetylase with activity towards 'Lys-9' and 'Lys-56' of histone H3. It modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. It is required for genomic stability and for normal IGF1 serum levels and normal glucose homeostasis. It also regulates cellular senescence and apoptosis. Unlike most sirtuins, SIRT6 preferentially removes long-chain fatty-acyl, rather than acetyl, protein modifications. This activity regulates secretion of the inflammation-associated protein TNF-.
Biovision | 7578 | Sirtuin 6 human recombinant DataSheet
Biomolecule/Target: Sirtuin 6
Synonyms: SIRT6, NAD-dependent Deacetylase Sirtuin-6; Mono-ADP-ribosyltransferase Sirtuin 6; SIR2-like Protein 6; SIR2L6
Alternates names: SIRT6, NAD-dependent Deacetylase Sirtuin-6; Mono-ADP-ribosyltransferase Sirtuin 6; SIR2-like Protein 6; SIR2L6
Taglines: A NAD-dependent protein deacetylase
NCBI Gene ID #: 6361
NCBI Gene Symbol: CCL17
Gene Source: Human
Accession #: Q92583
Recombinant: Yes
Source: E. coli
Purity by SDS-PAGEs: 97%
Assay: SDS-PAGE
Purity: N/A
Assay #2: N/A
Endotoxin Level: <0.1 EU/g by LAL method
Activity (Specifications/test method): N/A
Biological activity: Determined by its ability to chemoattract human T-Lymphocytes using a concentration range of 1.0-10.0 ng/ml.
Results: N/A
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: ~45.0 kDa. Human sirtuin 6 (aa 1-355) is fused at the N-terminus to a His-tag.
Concentration: N/A
Appearance: Liquid
Physical form description: 0.2 m-filtered solution in 55 mM Tris-Cl, pH 8.2, containing 150 mM NaCl.
Reconstitution Instructions: Reconstitute in HO to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers
Amino acid sequence: N/A
