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Product Description
Thymosin 1 is a peptide fragment derived from prothymosin alpha, a protein that in humans is encoded by the PTMA gene. Thymosin 1 is believed to be a major component of Thymosin Fraction 5 responsible for the activity of that preparation in restoring immune function in animals lacking thymus glands. It was the first of the peptides from Thymosin Fraction 5 to be completely sequenced and synthesized. Unlike thymosins, to which it is genetically and chemically unrelated, thymosin 1 is produced as a 28-amino acid fragment, from a longer, 113-amino acid precursor, prothymosin . It has been found to enhance cell-mediated immunity in humans as well as experimental animals.
Biovision | P1069 | Thymosin alpha 1 DataSheet
Biomolecule/Target: PTMA
Synonyms: Prothymosin alpha, PTMA, TMSA
Alternates names: Platelet Factor-4, CXCL4, Oncostatin A, Ironplact
Taglines: N/A
NCBI Gene ID #: 56744
NCBI Gene Symbol: CXCL4
Gene Source: Mouse
Accession #: Q9Z126
Recombinant: No
Source: E. Coli
Purity by SDS-PAGEs: 98%
Assay: SDS-PAGE
Purity: N/A
Assay #2: HPLC
Endotoxin Level: < 0.1 ng/g of protein (<1EU/g).
Activity (Specifications/test method): Determined by its ability to chemoattract human neutrophils using a concentration range of 10.0-100.0 ng/ml.
Biological activity: Determined by its ability to chemoattract human neutrophils using a concentration range of 10.0-100.0 ng/ml.
Results: N/A
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: 10.3 kDa
Concentration: N/A
Appearance: Lyophilized
Physical form description: Sterile filtered through a 0.2 micron filter. Lyophilized with no additives
Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.
Amino acid sequence: VTSAGPEESD GDLSCVCVKT ISSGIHLKHI TSLEVIKAGR HCAVPQLIAT LKNGRKICLD RQAPLYKKVI KKILES
