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Product Description
The tissue inhibitor of metalloproteinases (TIMP-1) is a glycoprotein with a molecular mass of about 28-kDa. The secreted protein consists of 184 amino acids, six disuilfide bonds and two glycosylation sites containing N-linked oligosaccharides. TIMP-1 specifically inhibits the extracellular-matrix-egradingmetalloproteinases such as collagenase, Gelatinase and stromelysin. It has no activity on mammalian membrane metallo-proteinases, procollagen peptidase, or on bacterial metalloproteinases such as thermolysin
Biovision | 7786 | TIMP-1 human recombinant DataSheet
Biomolecule/Target: N/A
Synonyms: Tissue Inhibitor of Matrix Metalloproteinases 1
Alternates names: Metalloproteinase inhibitor 1 (Erythroid-potentiating activity) (EPA) (Fibroblast collagenase inhibitor) (Collagenase inhibitor) (Tissue inhibitor of metalloproteinases 1) (TIMP-1)
Taglines: An inhibitor of MMPs
NCBI Gene ID #: 4049
NCBI Gene Symbol: TNFB
Gene Source: Human
Accession #: P01374
Recombinant: Yes
Source: Sf9 cells
Purity by SDS-PAGEs: 98%
Assay: SDS-PAGE
Purity: N/A
Assay #2: HPLC
Endotoxin Level: N/A
Activity (Specifications/test method): N/A
Biological activity: The ED as determined by the cytolysis of murine L929 cells in the presence of actinomycin D is < 0.05 ng/ml, corresponding to a specific activity of >2 x 10 units/mg.
Results: N/A
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: 28.0 kDa
Concentration: 50 µg/ml
Appearance: Liquid
Physical form description: In 50 mM Tris-HCl, pH 7; 200 mM NaCl; 5 mM CaCl; 1 M ZnCl; 0.05% Brij 35; 0,05% NaN
Reconstitution Instructions: Reconstitute in PBS to a concentration of 1 mg/ml. This solution can then be diluted into other aqueous buffers and store at 4°C for 1 week or 20°C for future use. For long term storage, it is recommended to add a carrier protein (0.1% HAS or BSA).
Amino acid sequence: N/A
