Product Description
Recombinant Human FGF-12 Protein [E. coli] | 100-391 | ReliaTech
Species: Human
Host / biotech: E. coli
Comment: N/A
Label: His-Tag
Clone / Antibody feature: N/A
Subcategory: Cytokines & Growth Factors
Category: Recombinant Protein
Synonyms: FGF12; FHF1; FGF12B
Isotype: N/A
Application: N/A
Detection Range: Data not available.
Species Reactivity/Cross reactivity: Human
Antigen: N/A
Description: FGF-12 is part of the Fibroblast Growth Factor (FGF) family which has a vast mitogenic and cell survival functions, and play a role in a range of biological activities, among them are embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. FGF-12 doesn’t obtain the N-terminal signal sequence present in the majority of the FGF family members, but it contains clusters of basic residues that act as a nuclear localization signal. When transfected into mammalian cells, FGF-12 accumulated in the nucleus, but was not secreted. FGF-12 is involved in nervous system development and function. FGF-12 binds to IB2 (islet brain-2), a cellular kinase scaffold, and voltage gated sodium channels and is also involved in intracellular signaling and ion exchange. FGF-12 is a single, non-glycosylated polypeptide chain produced in E. coli, having a molecular weight of 22.6 kDa and containing 201 amino acids (1-181). The FGF12 is fused to a 20 amino acid His tag at the N-terminus.
Purity Confirmation: > 90% by SDS-PAGE
Endotoxin: N/A
Formulation: liquid
Storage Handling Stability: N/A
Reconstituation: N/A
Molecular Weight: 22.6 kDa
Lenght (aa): 201
Protein Sequence: MSSHHHHHH SSGLVPRGSH MESKEPQLKG IVTRLFSQQG YFLQMHPDGT IDGTKDENSD YTLFNLIPVG LRVVAIQGVK ASLYVAMNGE YLYSSDVFT PECKFKESVF ENYYVIYSST LYRQQESGRA WFLGLNKEGQ IMKGNRVKKT KPSSHFVPKP IEVCMYREQS LHEIGEKQGR RKSSGTPTM NGGKVVNQDS T
NCBI Gene ID: 2257