Euro
USD
British Pound
NULL
![Recombinant Human IL-13 Variant Protein [E. coli]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/1280x1280/products/671401/929244/logo__42078.1651665136__84803.1651684267.jpg?c=2 "Recombinant Human IL-13 Variant Protein [E. coli]"){kind=logo}
![Recombinant Human IL-13 Variant Protein [E. coli]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/100x100/products/671401/929244/logo__42078.1651665136__84803.1651684267.jpg?c=2 "Recombinant Human IL-13 Variant Protein [E. coli]"){kind=logo}
Product Description
Recombinant Human IL-13 Variant Protein [E. coli] | 100-343S/100-343 | ReliaTech
Species: Human
Host / biotech: E. coli
Comment: N/A
Label: N/A
Clone / Antibody feature: N/A
Subcategory: Cytokines & Growth Factors
Category: Recombinant Protein
Synonyms: IL13; ALRH; BHR1; P600; IL-13
Isotype: N/A
Application: N/A
Detection Range: This IL-13 analog shows a two fold increase, relative to wild type IL-13, in bioactivity as measured by the in-vitro dose dependent activation of STAT6 and IL-13 dependent gene induction in transfected A201.1 cells. This analog has also been shown to exhibit increased in vivo activity compared to wild type IL-13, as measured by the induction of airway hyper-responsiveness.
Species Reactivity/Cross reactivity: Mouse, Human
Antigen: N/A
Description: IL-13 is an immunoregulatory cytokine produced primarily by activated Th2 cells, and also by mast cells and NK cells. Targeted deletion of IL-13 in mice resulted in impaired Th2 cell development and indicated an important role for IL-13 in the expulsion of gastrointestinal parasites. IL-13 exerts anti-inflammatory effects on monocytes and macrophages and it inhibits the expression of inflammatory cytokines such as IL-1β, TNF-α, IL-6 and IL-8. IL-13 has also been shown to enhance B cell proliferation and to induce isotype switching resulting in increased production of IgE. Blocking of IL-13 activity inhibits the pathophysiology of asthma. Human and murine IL-13 is cross-species reactive. A variant of IL-13 shows enhanced functional activity compared with the wild type IL-13. The genetic variant, termed human IL-13 analog, is a mature 114 amino acid protein with a substitution of Q for R at position 112.
Purity Confirmation: > 98% by SDS-PAGE & HPLC analyses
Endotoxin: < 0.1 ng/µg of protein (<1EU/µg)
Formulation: lyophilized
Storage Handling Stability: N/A
Reconstituation: N/A
Molecular Weight: 12.3 kDa
Lenght (aa): 114
Protein Sequence: MSPGPVPPST ALRELIEELV NITQNQKAPL CNGSMVWSIN LTAGMYCAAL ESLINVSGCS AIEKTQRMLS GFCPHKVSAG QFSSLHVRDT KIEVAQFVKD LLLHLKKLFR EGQFN
NCBI Gene ID: 3596
![Recombinant Human IL-13 Variant Protein [E. coli]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/500x659/products/671401/929244/logo__42078.1651665136__84803.1651684267.jpg?c=2 "Recombinant Human IL-13 Variant Protein [E. coli]"){kind=logo}
![Recombinant Human IL-13 Protein [E. coli]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/500x659/products/671391/929234/logo__42078.1651665136__80425.1651684265.jpg?c=2 "Recombinant Human IL-13 Protein [E. coli]"){kind=logo}
![Recombinant Human gAcrp30 Variant Protein [E. coli]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/500x659/products/671065/928908/logo__42078.1651665136__03181.1651684166.jpg?c=2 "Recombinant Human gAcrp30 Variant Protein [E. coli]"){kind=logo}
![Recombinant Human IL-17E Protein [E. coli]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/500x659/products/671434/929277/logo__42078.1651665136__23219.1651684277.jpg?c=2 "Recombinant Human IL-17E Protein [E. coli]"){kind=logo}
![Recombinant Human IL-17F Protein [E. coli]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/500x659/products/671439/929282/logo__42078.1651665136__49020.1651684278.jpg?c=2 "Recombinant Human IL-17F Protein [E. coli]"){kind=logo}
![Recombinant Human IL-22 Protein [E. coli]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/500x659/products/671465/929308/logo__42078.1651665136__95034.1651684285.jpg?c=2 "Recombinant Human IL-22 Protein [E. coli]"){kind=logo}