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Product Description
Recombinant Binuclease | RE002 | SAB Recombinant Enzyme
Source:
From yeast cells with cloned gene encoding genetically engineered Serratia marcescens endonuclease.
EC:
3.1.30.2
Synonyms:
Serratia marcescens Binuclease; unrestricted endonuclease
Form:
The product is available as lyophilized powder and also as buffered aqueous glycerol solution.
Specificity:
≥ 1000 kU/mg protein
Application:
Our Binuclease Endonuclease cleaves all forms of DNA and RNA, which makes it an ideal tool to eliminate nucleic acids (DNA and RNA) contamination in vaccine, antibody, cell therapy and other biological products for therapeutic use to meet FDA guidelines that nucleic acid contamination should be limited to 100 pg per dose in the end product. Binuclease reduces nucleic acid load and viscosity in cell lysates during purification to facilitate the filtration/ultrafiltration of solutions, reduce processing time, improve the separation of pellets and supernatants in centrifugations and increase the efficiency of chromatographic purification, resulting significant improvements on both yield and purity of cell-derived particles such as viruses, AAV vectors or inclusion bodies. Bioanalytical applications: Sample preparation for ELISA, chromatography or two- dimensional electrophoresis (protein mapping), and footprint analysis to get improved resolution and increased recovery of samples.
Storage Conditions:
-20℃ Recommended
