Euro
USD
British Pound
NULL
Product Description
Human Anti-cyclic citrullinated peptide antibody (CCP-Ab) ELISA Kit | AE62292HU | Abebio
Species Reactivity: Human (Homo sapiens)
Abbreviation: CCP-Ab
Alternative Name: N/A
Application: ELISA
Range: 12.35-1000 pg/mL
Sensitivity: 4.48 pg/mL
Intra-Assay: ≤4.1%
Inter-Assay: ≤7.8%
Recovery: 0, 94
Sample Type: Serum, Plasma, Other biological fluids
Detection Method: Competitive ELISA
Analysis Method : Qualitative
Test Principale: This assay employs the competitive enzyme immunoassay technique. The microtiter plate provided in this kit has been pre-coated with an antibody specific to CCP-Ab. Standards or samples are then added to the appropriate microtiter plate wells with a Horseradish Peroxidase (HRP) -conjugated CCP-Ab and incubated. The competitive inhibition reaction is launched between with HRP labeled CCP-Ab and unlabeled CCP-Ab with the antibody. A substrate solution is added to the wells and the color develops in opposite to the amount of CCP-Ab in the sample. The color development is stopped and the intensity of the color is measured.
Product Overview: The most prominent clinical syndrome associated with a disordered hypersecretion of Calcitonin is medullary carcinoma of the thyroid (MTC) . MTC is a tumor of the Calcitonin producing C-cells of the thyroid gland. Although MTC is rare, comprising 5 - 10% of all thyroid cancer, it is often fatal. It may occur sporadically or in a familial form that is transmitted as an autosomal dominant trait. MTC has great clinical importance because of its familial distribution. Further, it leant itself to be diagnosed early by serum Calcitonin and total cure for early sub-clinical disease is possible1. This is frequently associated with other clinical features and it has good potential for cure with surgery. Although a rare tumor, it can occur in a familial pattern1 as a Type II multiple endocrine neoplasia.
Stability: The stability of ELISA kit is determined by the loss rate of activity. The loss rate of this kit is less than 5% within the expiration date under appropriate storage condition. The loss rate was determined by accelerated thermal degradation test. Keep the kit at 37°C for 4 and 7 days, and compare O.D.values of the kit kept at 37°C with that of at recommended temperature. (referring from China Biological Products Standard, which was calculated by the Arrhenius equation. For ELISA kit, 4 days storage at 37°C can be considered as 6 months at 2 - 8°C, which means 7 days at 37°C equaling 12 months at 2 - 8°C) .
