Euro
USD
British Pound
NULL
Product Description
Amyloid beta oligomer-specific monoclonal antibody (OMAB), Biotinylated | AS10 932B | Agrisera
Immunogen: partly aggregated, recombinant peptide corresponding to the human Abeta (1-40), Amino acid sequence: D-A-E-F-R-H-D-S-G-Y-E-V-H-H-Q-K-L-V-F-F-A-E-D-V-G-S-N-K-G-A-I-I-G-L-M-V-G-G-V-V
Host: Mouse
Conjugation: N/A
Clonality: Monoclonal
Isotype: IgM
Purity: Affinity purified in PBS pH 7.4.
Format: Lyophilized
Tested Application: ELISA (ELISA), Immunohistochemistry (IHC)
Related Products: AS13 2716 | mAB-M | human Abeta protein (3-10) region, oligomer-specific, mouse monoclonal antibodiesAS13 2715 | mAB-O | human Abeta protein (3-10) region, oligomer specific, mouse monoclonal antibodiesAgrisera matching secondary antibody: Goat anti-mouse IgM (µ chain), HRP conjugated, min. cross-reactivity to human IgG/serum, AS10 969Secondary antibodies
Recommended Dilutions: Coating antibody at 2 µg/ml (ELISA), 1 : 500 (IHC)
Molecular weight: 4, 5 kDa
Confirmed Reactivity: Human Abeta oligomers only
Predicted Reactivity: Rat
Not reactive in: No confirmed exceptions from predicted reactivity are currently known
Additional Information: OMAB antibody is a versatile tool within research of Alzheimer's disease, A sandwhich ELISA illustrates its potential regarding its high selectivity towards A? oligomers
Background: Soluble oligomeric assemblies of the Amyloid-β peptide are today anticipated to be the direct cause regarding the Alzheimer pathology. As a consequence, oligomeric Aβ-assemblies constitute a very interesting therapeutic target. Identification of Aβ-oligomers is however, technically challenging due to there labile nature and low abundance. Abeta oligomer-specific OMAB antibody is based on the IgM isotype and represents a new concept of Aβ-oligomer binders using a combination of high avidity and very low monovalent affinity. This combination creates a selectivity of the antibody towards the oligomeric fraction and minimizes reactivity towards monomeric species.
Reconstitution: For reconstitution add 100 µl of sterile water
Storage: Store lyophilized/reconstituted at 4°C. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube.
TAIR Nnumbre: N/A
Category: Alzheimer's disease
Research Area: Pathology, Amyloid disorders
