Product Description
CO4 | Complement component C4, Biotin conjugated | IMS06-032-304 | Agrisera
Immunogen: full length native protein UniProt:P0C0L4 purified from human plasma
Host: Chicken
Conjugation: Biotin
Clonality: Polyclonal
Isotype: N/A
Purity: Immunogen affinity purified IgY in 0.15M sodium chloride, 0.02M sodium phosphate, 0.1% sodium azide., pH 7.2.
Format: Liquid
Tested Application: Western blot (WB)
Related Products: IMS02-032-303 | Anti-Complement component C4, chicken antibodiesIMS01-031-305 | Anti-Complement component C4c, chicken antibodiesIMS01-066-309 | Anti-Complement factor H, chicken antibodies
Recommended Dilutions: Use at an assay dependent dilution (WB)
Molecular weight: 193 kDa
Confirmed Reactivity: Human
Predicted Reactivity: Human
Not reactive in: No confirmed exceptions from predicted reactivity are currently known
Additional Information: Prior to conjugation: Only one precipitin arc in immunodiffusion against normal human serum or human C4, Only one precipitin arc in immunoelectrophoresis against normal human serum or human C4, Specific against human C4 alpha and beta chains in electroblotting when tested against normal human serum
Background: Complement component C4 consists of three polypeptide chains (alpha, molecular weight 95 kDa; beta, molecular weight 75 kDa and gamma, molecular weight 33 kDa) and is usually present in serum at 200-600 mg/L. It is a protein of the classical complement pathway. When activated by C1s, peptide C4a is released and the generated C4b binds C2 which is in turn cleaved by C1s to produce the classical pathway C3 convertase, namely C4b2a. C4b also has opsonin activity and binds to macrophages and neutrophils via their CR1 receptor.
Reconstitution: N/A
Storage: Store at 4°C; make aliquots to avoid working with a stock. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube.
TAIR Nnumbre: N/A
Category: Immunology
Research Area: Immunology