Product Description
Aldehyde dehydrogenases (ALDHs) mediate the NADP+-dependent oxidation of aldehydes into acids and play an important role in the detoxification of alcohol-derived acetaldehyde, as well as in lipid peroxidation and in the metabolism of corticosteroids, biogenic amines and neurotransmitters. ALDH5A1 (aldehyde dehydrogenase 5 family, member A1), also known as SSDH or SSADH, is a 535 amino acid protein that localizes to the mitochondria and belongs to the aldehyde dehydrogenase family. Expressed in a variety of tissues, including liver, heart, lung, brain, kidney and placenta, ALDH5A1 is required for gamma-aminobutyric acid (GABA) recycling from the synaptic cleft. Mutations of ALDH5A1 lead to succinate semialdehyde dehydrogenase deficiency (SSADH deficiency) that is characterized by severe ataxia and by mildly retarded psychomotor development.
Biovision | 6750 | ALDH5A1 Antibody DataSheet
Antibody Target: ALDH5A1
Target Alternative Name: ALDH5A1; SSADH; Succinate-semialdehyde dehydrogenase, mitochondrial; Aldehyde dehydrogenase family 5 members A1; NAD (+)-dependent succinic semialdehyde dehydrogenase.
Tag Line: Polyclonal Antibody to detect ALDH5A1 in human samples
Category: ALDH5A1
Host: Rabbit
Isotype: Rabbit IgG
Species Reactivities: Human.
Immunogen Sequence: This ALDH5A1 antibody is generated from rabbits immunized with human ALDH5A1 recombinant protein.
Accession #: P51649
Gene ID: 7915
Appearance: Colorless liquid
Form: Liquid
Concentration: N/A
Formulation: 100 µl of antibody in PBS with 0.09% (W/V) sodium azide
Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.
Application: Western blot, IHC, FACS.
Positive Control: Western blot: WiDr cell lysate, IHC: human brain tissue, FACS: WiDr cell lysate.
Application And Usages: Western blot: ~1:1000, IHC: ~1:50-1:100, FACS: ~1:10-1:50.
Country of Animal Origin: USA
Country of Manufacture: USA
Usage: For Research Use Only! Not to be used in humans.
Handling: The antibody solution should be gently mixed before use.
Western Blot Verified: Verified
Immunocytochemistry Verified: Verified
Immunofluorescence Verified: Not Verified
Immunoprecipitation Verified: Not Verified
FACS Verified:
ELISA Verified: Not Verified
ChIP Verified: Not Verified
Dot Blot Verified:
Flow Cytometry Verified: Verified