Product Description
Thromboxane A2 (TxA2) is a prostaglandin metabolite that is metabolically derived from arachidonic acid (AA) via the action of cyclooxygenases (COX1 in platelets and COX2 in monocytes and endothelial cells). TxA2 is a vasoactive agent that regulates blood flow and blood pressure. Additionally, it acts as a pro-thrombotic agent that promotes the activation and aggregation of platelets. However, TxA2 is highly unstable with a short half-life (20-30 secs). It is readily converted to a stable metabolite thromboxane B2, which further undergoes dehydrogenation to form 11-dehydro thromboxane B2 (11dhTxB2). 11dhTxB2 is excreted in urine and has a longer half-life than TxA2. The metabolite is unaffected by the ex vivo platelet activation and other pre-analytical variables and hence is a valid biomarker to determine platelet activity. 11dhTxB2 is found to be elevated in multiple atherothrombotic diseases. Additionally, an elevated level of 11dhTxB2 in urine indicates aspirin resistance in patients receiving antiplatelet aspirin therapy.
Biovision | A2165 | Anti-11-Dehydro TXB2 Antibody DataSheet
Antibody Target: 11-Dehydro TXB2
Target Alternative Name: 11-Dehydro-thromboxane B2, 11-Dehydro-txb2, 11-dehydrothromboxane B2, 11-Keto-thromboxane B2, 11dhTxB2 antibody
Tag Line: Recombinant mouse monoclonal antibody to detect 11-dehydro Thromboxane B2 expression in human urine samples
Category: Primary antibody
Host: Recombinant
Isotype: IgG1
Species Reactivities:
Immunogen Sequence:
Accession #:
Gene ID:
Appearance: Colorless liquid
Form: Liquid
Concentration:
Formulation: In 500 mM Diethanolamine, 1.0 M NaCl, 10 mM EDTA, 1% BSA, pH 8.7
Purification: Protein A purified
Application: ELISA
Positive Control:
Application And Usages: ELISA
Country of Animal Origin: USA
Country of Manufacture: USA
Usage: For Research Use Only! Not to be used in humans.
Handling: The antibody solution should be gently mixed before use.
Western Blot Verified: FALSE
Immunocytochemistry Verified: FALSE
Immunofluorescence Verified: FALSE
Immunoprecipitation Verified: FALSE
FACS Verified: FALSE
ELISA Verified: TRUE
ChIP Verified: FALSE
Dot Blot Verified: FALSE
Flow Cytometry Verified: FALSE