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Product Description
The research-grade biosimilar is Type II humanized monoclonal antibody that targets CD20 expressed on pre- and mature B lymphocyte cells. The antibody is glycoengineered to increase the binding of CD 64 and CD16 by 7-10 folds and improve antibody-dependent cellular cytotoxicity (ADCC). Additionally, the glycoengineered structure of the antibody helps recruit immune effector cells such as polymorphonuclear neutrophils (PMNs), which when activated, release inflammatory mediators, and promote phagocytosis. A previous study demonstrated that the binding of the antibody to CD20 causes rearrangement of the actin cytoskeleton, which causes the lysosomal compartment to expand. As a result, the lysosomal membrane becomes permeable, causing Cathepsin B to leak into the cytosol. Excessive leakage of Cathepsin B promotes cell death by necrosis. The original drug has been approved by the FDA to treat patients with chronic lymphocytic leukemia (CLL) in combination with Chlorambucil.
Biovision | A2180 | Anti-CD20 (Obinutuzumab), Humanized Antibody DataSheet
Antibody Target: CD20
Target Alternative Name: GA-101, GA101, R7159, RG7159, RO5072759, B1, S7, Bp35, CVID5, MS4A2, MS4A1, LEU-16
Tag Line: The biosimilar is a type II humanized monoclonal antibody that targets CD20 and induces B-cell lysis via antibody-dependent cellular cytotoxicity and antibody-dependent cellular phagocytosis
Category: Biosimilars
Host: Recombinant
Isotype: IgG1, kappa
Species Reactivities: Human
Immunogen Sequence: Human CD20
Accession #: DB08935
Gene ID:
Appearance: Colorless liquid
Form: Liquid
Concentration: 1 mg/ml
Formulation: In PBS, pH 7.5
Purification: Protein A purified
Application:
Positive Control:
Application And Usages: In vitro studies
Country of Animal Origin: USA
Country of Manufacture: USA
Usage: For Research Use Only! Not to be used in humans.
Handling: The antibody solution should be gently mixed before use.
Western Blot Verified: FALSE
Immunocytochemistry Verified: FALSE
Immunofluorescence Verified: FALSE
Immunoprecipitation Verified: FALSE
FACS Verified: FALSE
ELISA Verified: FALSE
ChIP Verified: FALSE
Dot Blot Verified: FALSE
Flow Cytometry Verified: FALSE
