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Product Description
Cytokine that binds to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation. Induces the activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells. Induces tyrosine phosphorylation of isoform 3 of CD28. Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4. Involved in immunoglobulin class switching. The antibody binds specifically to CD40L, a surface receptor expressed on activated T cells which acts as a costimulatory molecule to trigger immune responses. The antibody neutralizes CD40L function, as it blocks the interaction between CD40 and CD40L. When injected into cynomolgus monkeys, the antibody was found to have a T1/2 of 531? ±?155 hours.
Biovision | A1094 | Anti-CD40L (Ruplizumab), Human IgG1 Antibody DataSheet
Antibody Target: CD40LG
Target Alternative Name: CD40 ligand; tumour necrosis factor ligand superfamily member 5; TNFSF5; CD154; tumour necrosis factor related activation protein; TRAP
Tag Line: Monoclonal antibody to detect CD40L in human samples.
Category: Immunology
Host: Recombinant
Isotype: Human IgG1, kappa
Species Reactivities: Human
Immunogen Sequence: Human CD40L
Accession #: P29965
Gene ID: 959
Appearance: Colorless liquid
Form: Liquid
Concentration:
Formulation: Supplied in PBS, pH 7.5
Purification: SOURCE: CHO cells
Application: Block; FC
Positive Control: N/A
Application And Usages:
Country of Animal Origin: USA
Country of Manufacture: USA
Usage: For Research Use Only! Not to be used in humans
Handling: The antibody solution should be gently mixed before use
Western Blot Verified: Not Verified
Immunocytochemistry Verified: Not Verified
Immunofluorescence Verified: Not Verified
Immunoprecipitation Verified: Not Verified
FACS Verified: Not Verified
ELISA Verified: Not Verified
ChIP Verified: Not Verified
Dot Blot Verified: Not Verified
Flow Cytometry Verified: Not Verified
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