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Product Description
Galiximab is a primatized mAb which consists of human constant and primate (cynomolgus macaque) variable regions and binds specifically to CD80. CD80 is a surface glycoprotein and a member of the B7 family of co-stimulatory molecules. CD80 antigen regulates T cell activation (through interacting with CD28 or CD152) and is expressed transiently in antigen-presenting cells, T cells and normal B cells, and expressed constitutively on various subtypes of B-cell lymphomas. Galiximab acts to decrease in cell proliferation, inhibition of the constitutively active NF-?B pathway, increase in apoptosis and ADCC against various B-cell lymphoma cell lines. Galiximab affects CD28 and CD152 interactions with CD80.
Biovision | A2011 | Anti-CD80 (Galiximab), Human IgG1, lambda Antibody DataSheet
Antibody Target: CD80
Target Alternative Name: B7-1; T-lymphocyte activation antigen CD80; Activation B7-1 antigen; BB1; CTLA-4 counter-receptor B7.1; B7
Tag Line: Recombinant monoclonal antibody manufactured using Recombinant Platform with variable regions from the therapeutic antibody IDEC-114 (Galiximab) to detect CD80 expression in humans
Category: Biosimilars
Host: Recombinant
Isotype: Human IgG1, lambda
Species Reactivities: Human
Immunogen Sequence: Galiximab was prepared by immunizing cynomolgus monkeys with recombinant CD80 antigen. The variable regions of the light and heavy chains were then cloned by being incorporated into a cassette vector (N5LG1) containing human constant region genes and subsequently transfected into the Dg44 CHO cell line
Accession #: P33681
Gene ID: 941
Appearance: Colorless liquid
Form: Liquid
Concentration: 1 mg/ml
Formulation: Supplied in PBS, pH 7.5
Purification: SOURCE: CHO cells
Application: Block, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP), Western Blotting, Modulate, Flow Cytometry, ELISA
Positive Control:
Application And Usages: WB, ELISA, IP, IF, IHC, FC, Block, Modulate
Country of Animal Origin: USA
Country of Manufacture: USA
Usage: For Research Use Only! Not to be used in humans.
Handling: The antibody solution should be gently mixed before use.
Western Blot Verified: False
Immunocytochemistry Verified: False
Immunofluorescence Verified: True
Immunoprecipitation Verified: False
FACS Verified: False
ELISA Verified: False
ChIP Verified: False
Dot Blot Verified: False
Flow Cytometry Verified: False
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