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Product Description
The research-grade biosimilar is a fully human IgG1 monoclonal antibody that is directed against connective tissue growth factor (CTGF). CTGF is a cysteine-rich glycoprotein that is found in several cell types such as fibroblasts, smooth muscle cells, and cartilaginous cells. It is known to be involved in multiple pathological and biological processes such as angiogenesis, tumor development, skin diseases, and osteogenesis. Studies have demonstrated that increased CTGF expression is found in fibrotic lesions, which suggests its role in causing fibrosis. Fibrosis is one of the hallmarks of muscular dystrophies, resulting in weakness and injury of the muscles. Increased expression of CTGF is also observed in muscular dystrophies. Binding of the antibody to CTGF decreases fibrosis in muscles and improves the function of the muscles. The original monoclonal antibody received Fast Track designation from the FDA to treat idiopathic pulmonary fibrosis (IPF) and pancreatic cancer. Currently, the original antibody is undergoing clinical trials to treat Duchenne muscular dystrophy.
Biovision | A2207 | Anti-CTGF (Pamrevlumab), Human IgG1 Antibody DataSheet
Antibody Target: CTGF
Target Alternative Name: CCN2, NOV2, HCS24, IGFBP8, IGFBP-8, IBP-8, IGF-Binding Protein 8, CCN Family Member 2
Tag Line: The biosimilar is a human monoclonal antibody that targets CTGF, a pro-inflammatory protein that plays a key role in the progression of fibrosis and other proliferation disorders
Category: Biosimilars
Host: Recombinant
Isotype: IgG1, kappa
Species Reactivities:
Immunogen Sequence: Human CTGF
Accession #:
Gene ID:
Appearance: Colorless liquid
Form: Liquid
Concentration: Lot specific
Formulation: In PBS, pH 7.5
Purification: Protein A purified
Application:
Positive Control:
Application And Usages:
Country of Animal Origin: USA
Country of Manufacture: USA
Usage: For Research Use Only! Not to be used in humans.
Handling: The antibody solution should be gently mixed before use.
Western Blot Verified: FALSE
Immunocytochemistry Verified: FALSE
Immunofluorescence Verified: FALSE
Immunoprecipitation Verified: FALSE
FACS Verified: FALSE
ELISA Verified: FALSE
ChIP Verified: FALSE
Dot Blot Verified: FALSE
Flow Cytometry Verified: FALSE
