Product Description
The research-grade biosimilar is a recombinant human IgG1 monoclonal antibody that targets interferon-gamma (IFN-?). Interferon-gamma is a cytokine secreted by immune cells such as natural killer (NK), natural killer T (NKT) cells, and cytotoxic T-lymphocyte cells in response to pathogen attack. It can directly inhibit viral replication and also stimulate and regulate inflammation. Increased inflammation or autoimmune diseases such as arthritis, lupus, and primary hemophagocytic lymphohistiocytosis (HLH) cause abnormally high levels of interferon-gamma. The original monoclonal antibody non-competitively binds to interferon-gamma and prevents its association with interferon receptors located on the cell surface, and ultimately causing inactivation of pro-inflammatory signaling pathways. The original monoclonal antibody received FDA approval to treat adult and pediatric patients suffering from primary hemophagocytic lymphohistiocytosis (HLH) and intolerant to HLH therapy.
Biovision | A2270 | Anti-IFN-? (Emapalumab), Human IgG1 Antibody DataSheet
Antibody Target: Interferon gamma (IFN-?)
Target Alternative Name: IFG, IFI, IMD69, IFNG, Interferon Gamma, Immune Interferon, IFN-Gamma
Tag Line: The biosimilar is a human IgG1 monoclonal antibody targeting Interferon-gamma (IFN-?)
Category: Biosimilars
Host: Recombinant
Isotype: IgG1, lambda
Species Reactivities: Human
Immunogen Sequence: Human IFN-?
Accession #: DB14724
Gene ID: 3458
Appearance: Colorless liquid
Form: Liquid
Concentration:
Formulation: In PBS, pH 7.5
Purification: Protein A purified
Application:
Positive Control:
Application And Usages:
Country of Animal Origin: USA
Country of Manufacture: USA
Usage: For Research Use Only! Not to be used in humans.
Handling: The antibody solution should be gently mixed before use.
Western Blot Verified: FALSE
Immunocytochemistry Verified: FALSE
Immunofluorescence Verified: FALSE
Immunoprecipitation Verified: FALSE
FACS Verified: FALSE
ELISA Verified: FALSE
ChIP Verified: FALSE
Dot Blot Verified: FALSE
Flow Cytometry Verified: FALSE