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Product Description
Lymphocyte-activation gene 3 (LAG3) is an immune checkpoint protein expressed on activated T cells, NK cells, B cells, and plasmacytoid dendritic cells. It acts as a negative regulator of T cells by suppressing their activation and inhibiting immune response. The T cell inhibition is caused by the binding of LAG3 to an antigen-presenting cell called MHC Class II. LAG3 is also involved in the maturation and activation of dendritic cells. LAG3 was found to be co-expressed with PD1 and caused T-cell exhaustion. LAG3 is highly expressed in tumor-infiltrating leukocytes (TILs) of various cancers, thereby making it a promising anti-cancer target.
Biovision | A2275 | Anti-LAG3 Antibody (Clone# LAG3/3261) DataSheet
Antibody Target: LAG3
Target Alternative Name: CD223, LAG3, FDC, LAG-3
Tag Line: Mouse monoclonal antibody to detect the expression of LAG3 in human samples
Category: Primary antibody
Host: Mouse
Isotype: IgG2a, kappa
Species Reactivities: Human
Immunogen Sequence: Recombinant full-length human LAG3 protein
Accession #: P18627
Gene ID: 3902
Appearance: Colorless liquid
Form: Liquid
Concentration:
Formulation: In 10 mM PBS
Purification: Protein A/G purified
Application:
Positive Control:
Application And Usages:
Country of Animal Origin: USA
Country of Manufacture: USA
Usage: For Research Use Only! Not to be used in humans.
Handling: The antibody solution should be gently mixed before use.
Western Blot Verified: FALSE
Immunocytochemistry Verified: FALSE
Immunofluorescence Verified: FALSE
Immunoprecipitation Verified: FALSE
FACS Verified: FALSE
ELISA Verified: FALSE
ChIP Verified: FALSE
Dot Blot Verified: FALSE
Flow Cytometry Verified: FALSE
![LAG3 Antibody [7A7]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/500x659/products/552511/759783/porsci_lo__79508.1648973713__30028.1649084887.png?c=2 "LAG3 Antibody [7A7]")
