Product Description
The research-grade biosimilar is a fully human IgG4 monoclonal antibody that targets the human cell surface receptor programmed cell death-1 (PD-1), an immune checkpoint protein with neoplastic functions. The antibody binds to PD-1 and prevents the association with its ligands PD-L1 and PD-L2. This results in inhibition of PD-1 and its downstream signaling, leading to the activation of T-cells and T-cell mediated immune response to inhibit tumor growth. The original drug is approved in China to treat relapsed or refractory patients with classic Hodgkins lymphoma, after the second-line of chemotherapy. Currently, this drug is in the process of FDA approval for use in the United States. The drug is undergoing clinical trials to test for safety and efficacy in the treatment of cancers such as non-small cell lung cancer and esophageal cancer
Biovision | A2156 | Anti-PD-1 (Sintilimab), Human IgG4 Antibody DataSheet
Antibody Target: PD-1
Target Alternative Name: IBI-308, PDCD1, PD1, CD279
Tag Line: The biosimilar is a human monoclonal antibody that targets PD-1, inhibits PD-1 mediated signaling, and restores immune responses against tumor cells. The original drug is approved for the treatment of Hodgkins lymphoma and is currently in clinical trials to treat various cancers
Category: Biosimilars
Host: Recombinant
Isotype: Human IgG4, kappa
Species Reactivities: Human
Immunogen Sequence: Human PD-1
Accession #:
Gene ID:
Appearance: Colorless liquid
Form: Liquid
Concentration: 1 mg/ml
Formulation: In PBS, pH 7.5
Purification: Protein A purified
Application:
Positive Control:
Application And Usages:
Country of Animal Origin: USA
Country of Manufacture: USA
Usage: For Research Use Only! Not to be used in humans.
Handling: The antibody solution should be gently mixed before use.
Western Blot Verified: FALSE
Immunocytochemistry Verified: FALSE
Immunofluorescence Verified: FALSE
Immunoprecipitation Verified: FALSE
FACS Verified: FALSE
ELISA Verified: FALSE
ChIP Verified: FALSE
Dot Blot Verified: FALSE
Flow Cytometry Verified: FALSE