Product Description
The research-grade biosimilar is a humanized IgG1 monoclonal antibody that specifically targets Signaling Lymphocytic Activation Molecule Family member 7 (SLAMF7), a cell surface glycoprotein that is highly expressed on NK and multiple myeloma (MM) cells. The antibody has a dual mechanism of action: the direct effect involves the binding of the antibody to the Fc receptor (CD16), an extracellular portion of SLAMF7 on NK cells which ultimately triggers cell death via antibody-dependent cell cytotoxicity (ADCC); the indirect effect involves cell tagging wherein the Fab portion of the antibody binds to SLAMF7 on MM cells. These cells are recognized by NK cells that cause release of degranulated cytotoxic granules and lysis of MM cells. The original antibody was approved by the FDA as a combination treatment for patients with relapsed multiple myeloma.
Biovision | A2218 | Anti-SLAMF7 (Elotuzumab), Humanized Antibody DataSheet
Antibody Target: SLAMF7
Target Alternative Name: BMS-901608, HuLuc63, PDL063, PDL-06319A, CS1, CD319, CRACC
Tag Line: The biosimilar is a humanized monoclonal antibody that targets SLAMF7 by NK cell mediated antibody-dependent cellular cytotoxicity (ADCC). The original antibody is approved to treat patients suffering from multiple myeloma
Category: Biosimilars
Host: Recombinant
Isotype: IgG1, kappa
Species Reactivities: Human
Immunogen Sequence: Human SLAMF7
Accession #: DB06317
Gene ID:
Appearance: Colorless liquid
Form: Liquid
Concentration: 1 mg/ml
Formulation: In PBS, pH 7.5
Purification: Protein A purified
Application:
Positive Control:
Application And Usages:
Country of Animal Origin: USA
Country of Manufacture: USA
Usage: For Research Use Only! Not to be used in humans.
Handling: The antibody solution should be gently mixed before use.
Western Blot Verified: FALSE
Immunocytochemistry Verified: FALSE
Immunofluorescence Verified: FALSE
Immunoprecipitation Verified: FALSE
FACS Verified: FALSE
ELISA Verified: FALSE
ChIP Verified: FALSE
Dot Blot Verified: FALSE
Flow Cytometry Verified: FALSE