Product Description
The research-grade biosimilar is a fully human IgG2 monoclonal antibody that specifically targets receptor activator of nuclear factor kappa-B ligand (RANKL), a protein that plays a key role in the formation, function, and survival of osteoclasts. RANKL belongs to the TNF superfamily of ligands. Interaction with the receptor (RANK) expressed on pre-osteoclast and mature osteoclast cells results in the activation, migration, differentiation, and fusion of hematopoietic cells of osteoclast lineage, and promotes bone resorption. By preventing the RANKL-RANK interaction, the antibody inhibits bone resorption and increases bone mass density and strength, thus decreasing the risk of hip, vertebral, and non-vertebral fractures. The original monoclonal antibody received approval from the FDA for the treatment of osteoporosis in postmenopausal women, and to treat patients with bone metastases
Biovision | A2150 | Anti-TNFSF11 (Denosumab), Human IgG2 Antibody DataSheet
Antibody Target: TNFSF11
Target Alternative Name: CD254, ODF, OPGL, sOdf, OPTB2, RANKL, TNLG6B, TRANCE, hRANKL2
Tag Line: The biosimilar is a human monoclonal antibody that targets RANKL and inhibits the binding to its receptor RANK, thus reducing bone resorption and increasing bone mass and strength.
Category: Biosimilars
Host: Recombinant
Isotype: IgG2, kappa
Species Reactivities: Human
Immunogen Sequence: Human TNFSF11
Accession #: DB06643
Gene ID:
Appearance: Colorless liquid
Form: Liquid
Concentration: Lot specific
Formulation: In PBS, pH 7.5
Purification: Protein A purified
Application:
Positive Control:
Application And Usages:
Country of Animal Origin: USA
Country of Manufacture: USA
Usage: For Research Use Only! Not to be used in humans.
Handling: The antibody solution should be gently mixed before use.
Western Blot Verified: FALSE
Immunocytochemistry Verified: FALSE
Immunofluorescence Verified: FALSE
Immunoprecipitation Verified: FALSE
FACS Verified: FALSE
ELISA Verified: FALSE
ChIP Verified: FALSE
Dot Blot Verified: FALSE
Flow Cytometry Verified: FALSE