Product Description
The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand.
Biovision | A1937 | Anti-ERCC1 Antibody DataSheet
Antibody Target: ERCC1
Target Alternative Name: ERCC1; COFS4; RAD10; UV20; DNA excision repair protein ERCC-1
Tag Line: Affinity purified rabbit polyclonal antibody to ERCC1
Category: Primary antibody
Host: Rabbit
Isotype: IgG
Species Reactivities: Mouse, Human
Immunogen Sequence: Recombinant fusion protein corresponding to aa 1-323 of human ERCC1 (NP_973730.1)
Accession #: P07992
Gene ID: 2067
Appearance: Liquid
Form: Liquid
Concentration:
Formulation: In PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Purification: Affinity purified
Application: Immunofluorescence (IF), Western Blotting
Positive Control:
Application And Usages: IF 1:50 - 1:200, WB 1:500 - 1:2000
Country of Animal Origin: USA
Country of Manufacture: USA
Usage: For Research Use Only! Not to be used in humans.
Handling: The antibody solution should be gently mixed before use.
Western Blot Verified: True
Immunocytochemistry Verified: False
Immunofluorescence Verified: True
Immunoprecipitation Verified: False
FACS Verified: False
ELISA Verified: False
ChIP Verified: False
Dot Blot Verified: False
Flow Cytometry Verified: False