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Product Description
Protein arginine deiminases (PADs) are a family of guanidine-modifying enzymes that catalyze the post-translational modification of target proteins by converting arginine to citrulline. Excessive citrullination of proteins may result in disease states. PAD2 is the most widely expressed and evolutionarily conserved family member. Known substrates for PAD2 include myelin basic protein and vimentin, and PAD2 is thought to play a role in the onset and progression of neurodegenerative diseases such as Alzheimer's and multiple sclerosis. PAD2 may also play a role in transcriptional regulation as it is capable of citrullinating histone H3.
Biovision | A2322 | Anti-PAD2 Polyclonal Antibody DataSheet
Antibody Target:
Target Alternative Name: Peptidyl Arginine Deiminase 2; PDI2; Protein-Arginine Deiminase Type II; EC 3.5.3.15; KIAA0994; PAD-H19; PADI2
Tag Line: Potentially involved in autoimmune diseases
Category: GM-CSF
Host: Rabbit
Isotype: Rabbit IgG
Species Reactivities: Human
Immunogen Sequence: Recombinant Human PAD2 protein (amino acids 1 to 665)
Accession #: Q9Y2J8
Gene ID: 11240
Appearance:
Form: Rabbit polyclonal
Concentration:
Formulation: 0.01 M PBS, pH 7.4 with 50% glycerol, 0.03% Proclin 300
Purification: Protein G purification
Application: Immunofluorescence (IF) Immunohistochemistry (IHC) Western Blotting
Positive Control:
Application And Usages:
Country of Animal Origin: USA
Country of Manufacture: USA
Usage: For Research Use Only! Not to be used in humans.
Handling: The antibody solution should be gently mixed before use.
Western Blot Verified: FALSE
Immunocytochemistry Verified: TRUE
Immunofluorescence Verified: FALSE
Immunoprecipitation Verified: TRUE
FACS Verified: FALSE
ELISA Verified: FALSE
ChIP Verified: TRUE
Dot Blot Verified: FALSE
Flow Cytometry Verified: FALSE
