Product Description
This gene encodes a member of the family of de-ubiquitinating enzymes, which belongs to the peptidase C19 superfamily. The encoded protein is a ubiquitin-specific protease that is required for TNF-alpha (tumor necrosis factor alpha) -induced NF-kB (nuclear factor kB) signaling. This protein deubiquitinates polyubiquitinated target proteins such as fatty acid synthase, murine double minute 2 (MDM2), MDM4/MDMX, and cyclin D1. MDM2 and MDM4 are negative regulators of the p53 tumor suppressor and cyclin D1 is required for cell cycle G1/S transition. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
Biovision | A2146 | Anti-USP2 Antibody DataSheet
Antibody Target: USP2
Target Alternative Name: 41 kDa ubiquitin specific protease, 41 kDa ubiquitin-specific protease, Deubiquitinating enzyme 2, Ubiquitin carboxyl terminal hydrolase 2, Ubiquitin carboxyl-terminal hydrolase 2, ubiquitin specific peptidase 2, Ubiquitin specific processing protease 2, Ubiquitin specific protease 12, Ubiquitin specific protease 9, Ubiquitin thioesterase 2, Ubiquitin-specific-processing protease, UBP-t, UBP2, UBP41, USP2, USP9
Tag Line: Rabbit polyclonal antibody to detect the expression of USP2 in human and mouse samples
Category: Primary antibody
Host: Rabbit
Isotype: IgG
Species Reactivities: Mouse,Human
Immunogen Sequence: Recombinant Human Ubiquitin carboxyl-terminal hydrolase 2 protein
Accession #: O75604
Gene ID: 9099
Appearance: Colorless liquid
Form: Liquid
Concentration:
Formulation: In 0.01 M PBS, pH 7.4, 50% Glycerol, 0.03% proclin 300
Purification: Protein G purified
Application: Immunofluorescence (IF),Western Blotting
Positive Control:
Application And Usages: WB 1:1000-1:5000, IF 1:50-1:200
Country of Animal Origin: USA
Country of Manufacture: USA
Usage: For Research Use Only! Not to be used in humans.
Handling: The antibody solution should be gently mixed before use.
Western Blot Verified: TRUE
Immunocytochemistry Verified: FALSE
Immunofluorescence Verified: TRUE
Immunoprecipitation Verified: FALSE
FACS Verified: FALSE
ELISA Verified: FALSE
ChIP Verified: FALSE
Dot Blot Verified: FALSE
Flow Cytometry Verified: FALSE