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Product Description
Cathepsin L is a normal lysosomal cysteine endoproteases that is expressed in all cells. The latent 39 kDa pro-Cathepsin L must be processed by cleavage of the 96 amino acid pro-peptide, to generate the active two-chain form made up of 21 and 5 kDa subunits. Mature Cathepsin L is normally localized in the lysosomes where it plays a major role in intracellular protein catabolism. The fact that Cathepsin L is also capable of degrading extracellular matrix proteins s?ggests that it may play a role in invasion and metastasis and could be a useful prognostic indicator for cancer.
Biovision | 3192 | Cathepsin L Antibody DataSheet
Antibody Target: Cathepsin L
Target Alternative Name: CTSL, CATL, CTSL1, MEP, EC 3.4.22.15
Tag Line:
Category: Cathepsin
Host: Rabbit
Isotype: Rabbit IgG
Species Reactivities: Human
Immunogen Sequence: Synthetic peptide surrounding amino acid 223 of human Cathepsin L
Accession #: P07711
Gene ID: 1514
Appearance: Colorless liquid
Form: Liquid
Concentration: 0.2 mg/ml
Formulation: 100 µg (0.2 mg/ml) affinity purified rabbit anti-cathepsin L polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.1% BSA, 0.01% thimerosal.
Purification: Affinity purified
Application: Western blot, Immunohistochemistry
Positive Control: Western Blot: Jurkat cell lysate. IHC: Kidney tissue
Application And Usages: Western blotting (0.5-4 µg/ml), and Immunohistochemistry (5 µg/ml). However, the optimal conditions should be determined individually. Jurkat cell lysate (Cat.# 2401-100) can be used as a positive control. Detects both the proenzyme and the mature form of cathepsin L
Country of Animal Origin: China
Country of Manufacture: USA
Usage: For Research Use Only! Not to be used in humans.
Handling: The antibody solution should be gently mixed before use.
Western Blot Verified: Verified
Immunocytochemistry Verified: Verified
Immunofluorescence Verified: Not Verified
Immunoprecipitation Verified: Not Verified
FACS Verified:
ELISA Verified: Not Verified
ChIP Verified: Not Verified
Dot Blot Verified:
Flow Cytometry Verified: Not Verified
