Product Description
Histone H1.4 is a nuclear protein that binds to linker DNA between nucleosomes to form chromatin fibers. Histone H1.4 is expressed in most somatic cell types, and is necessary for the ordering of nucleosomes into higher-order structures and the compaction of chromatin into its condensed form. The arginine at position 53 can be citrullinated by protein-arginine deiminase 4 (PAD4), which releases Histone H1.4 from the histone complex, leading to chromatin decondensation. Aberrations in Histone H1.4 has been linked to intellectual disability disorders such as Rahman Syndrome.
Biovision | A2317 | Citrullinated Histone H1.4 (R53) Antibody DataSheet
Antibody Target: Human Histone H1.4 citrullinated at R53
Target Alternative Name: H1.4 Linker Histone, Cluster Member; Histone Cluster 1 H1 Family Member E; H1 Histone Family, Member 4; Histone Cluster 1, H1e; Histone 1, H1e; Histone H1s-4; Histone H1.4; Histone H1b; HIST1H1E; H1s-4; H1.4; H1F4; DJ221C16.5; RMNS; H1-4; H1E; H1e
Tag Line: A critical mediator of higher-order chromatin structure
Category: GM-CSF
Host: Rabbit
Isotype: Rabbit IgG
Species Reactivities: Human
Immunogen Sequence: Synthetic peptide of human histone H1.4 citrullinated at R53
Accession #: P10412
Gene ID: 3008
Appearance: Liquid
Form: Rabbit polyclonal
Concentration:
Formulation: TBS, pH 7.4, with 50% glycerol, 0.1% BSA, 0.02% sodium azide
Purification: Peptide affinity purification
Application: Western Blotting
Positive Control:
Application And Usages:
Country of Animal Origin: USA
Country of Manufacture: USA
Usage: For Research Use Only! Not to be used in humans.
Handling: The antibody solution should be gently mixed before use.
Western Blot Verified: FALSE
Immunocytochemistry Verified: TRUE
Immunofluorescence Verified: FALSE
Immunoprecipitation Verified: FALSE
FACS Verified: FALSE
ELISA Verified: FALSE
ChIP Verified: FALSE
Dot Blot Verified: FALSE
Flow Cytometry Verified: FALSE