Product Description
Biovision | PKF118-310 | B3373
Description: PKF118-310 is an antagonist of the Tcf4/b-catenin signaling. It disrupts binding of β-catenin to a GST-Tcf4 fusion protein in HCT116 cell lysates (IC50 = 0.8 µM). PKF118-310 inhibits expression of survivin and induces apoptosis in HCC, colon tumor and lymphocytic leukemia cell lines.
Alternate Name/Synonyms: 1,6-dimethyl-pyrimido[5,4-e]-1,2,4-triazine-5,7(1H,6H)-dione Toxoflavin NSC 67078
Appearance: Off-white to light brown Solid
Formulation:
CAS Number: 84-82-2
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₇H₇N₅O₂
Molecular Weight: 193.16
Cell-Permeable?: True
Purity: ≥98% by HPLC
Solubilities: ~10 mg/ml Water
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
ne: Tcf4/b-catenin signaling inhibitorMDL Number: MFCD00459812
PubChem CID: 66541
PubChem CID Link: https://pubchem.ncbi.nlm.nih.gov/compound/66541
SMILES: CN1C2=NC(=O)N(C(=O)C2=NC=N1)C
InChi: InChI=1S/C7H7N5O2/c1-11-6(13)4-5(10-7(11)14)12(2)9-3-8-4/h3H,1-2H3
InChi Key: SLGRAIAQIAUZAQ-UHFFFAOYSA-N
Category: Biochemicals