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Product Description
Biovision | SC-75741 | B3361
Description: SC-75741 is a potent NF-κB inhibitor (EC50 = 200 nM) that efficiently blocks influenza virus propagation. The mechanism of SC-75741 action involves impaired DNA binding of the NF-κB subunit p65, resulting in reduced expression of cytokines, chemokines, and pro-apoptotic factors, subsequent inhibition of caspase activation and block of caspase-mediated nuclear export of viral ribonucleoproteins.
Alternate Name/Synonyms: N-(6-benzoyl-1H-benzimidazol-2-yl)-2-(1-thieno[3,2-d]pyrimidin-4-yl-4-piperidinyl)-4-thiazolecarboxamide SC75741
Appearance: White to off-white solid
Formulation:
CAS Number: 913822-46-5
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₉H₂₃N₇O₂S₂
Molecular Weight: 565.67
Cell-Permeable?: True
Purity: ≥97% by HPLC
Solubilities: ~2 mgHandling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Tag Line: A NF-kappaB inhibitor
MDL Number:
PubChem CID: 23661638
PubChem CID Link: https://pubchem.ncbi.nlm.nih.gov/compound/23661638
SMILES: C1CN(CCC1C2=NC(=CS2)C(=O)NC3=NC4=C(N3)C=C(C=C4)C(=O)C5=CC=CC=C5)C6=NC=NC7=C6SC=C7
InChi: InChI=1S/C29H23N7O2S2/c37-24(17-4-2-1-3-5-17)19-6-7-20-22(14-19)34-29(33-20)35-27(38)23-15-40-28(32-23)18-8-11-36(12-9-18)26-25-21(10-13-39-25)30-16-31-26/h1-7,10,13-16,18H,8-9,11-12H2,(H2,33,34,35,38)
InChi Key: QNZVBFMXWNWVKG-UHFFFAOYSA-N
Category: Biochemicals
