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Product Description
B2M, also known as β2-Microglobulin or CDABP0092, is a component of MHC class I molecules found expression in all nucleated cells (excludes red blood cells). The major function of MHC class I moleculesis is to display fragments of proteins from within the cell to T-cells and cells containing foreign proteins will be attacked. B2M(β2-Microglobulin) is a low molecular weight protein. It was demonstrated that B2M(β2-Microglobulin) was localized in the membranes of nucleated cells and was found to be associated with HL-A antigens. Beta 2-microglobulin is present in small amounts in serum, csf, and urine of normal people, and to a much greater degree in the urine and plasma of patients with tubular proteinaemia, renal failure, or kidney transplants. For the diagnosis of multiple myeloma, the serum β2-microglobulin level is one of the prognostic factors incorporated into the International Staging System. The serum β2-microglobulin level is elevated (>2.7 mg/L) in 75% of patients at the time of diagnosis.
Biovision | P1432 | Beta 2 Microglobulin, Human Urine DataSheet
Biomolecule/Target :
Synonyms: B2M, BMG, beta-2M
Alternates names: B2M, BMG, beta-2M
Taglines:
NCBI Gene ID #: 567
NCBI Gene Symbol: B2M
Gene Source: Human
Accession #: P61769
Recombinant: False
Source: Human urine
Purity by SDS-PAGE: >98%
Assay: SDS-PAGE.
Purity:
Assay #2:
Endotoxin Level:
Activity (Specifications/test method):
Biological activity:
Results:
Binding Capacity:
Unit Definition:
Molecular Weight: 12 kDa
Concentration:
Appearance: Liquid protein
Physical form description: Liquid
Reconstitution Instructions:
Amino acid sequence:
Handling: Centrifuge the vial prior to opening.
Usage:
