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Product Description
Dimethylarginine Dimethylaminohydrolase (DDAH) metabolizes asymmetric dimethyl arginine (ADMA) to L-citrulline and dimethylamine, and NG-monomethyl arginine (MMA) to L-citrulline and monomethylamine. Two isoforms, DDAH1 and DDAH2 have been found in mammalian cells. DDAH1 is widely expressed, especially in liver and kidney. DDAH2 predominates in vascular endothelium and expressed selectively in the kidney.
Biovision | P1583 | DDAH1, Human Recombinant DataSheet
Biomolecule/Target :
Synonyms: DDAH-1, dimethylargininase-1
Alternates names: DDAH-1, dimethylargininase-1
Taglines: Regulates of nitric oxide generation
NCBI Gene ID #: 23576
NCBI Gene Symbol: DDAH1
Gene Source: Human
Accession #: O94760
Recombinant: TRUE
Source: E. coli
Purity by SDS-PAGE: >95%
Assay: SDS - PAGE
Purity:
Assay #2:
Endotoxin Level:
Activity (Specifications/test method): ≥ 5 mU/mg. Measured by its ability to hydrolyze asymmetric dimethylarginine to L-citrulline and dimethylamine by using BioVison’s DDAH Activity Fluorometric Assay Kit (Catalog # K2051)
Biological activity:
Results:
Binding Capacity:
Unit Definition: One unit of DDAH is defined as the amount of enzyme that hydrolyzes 1 umol of asymmetric dimethyl arginine (ADMA) to L-citrulline per min at 37 °C under the assay conditions.
Molecular Weight: 31.4 KDa
Concentration:
Appearance: Liquid
Physical form description: In 50 mM Tris Buffer PH 8.0, 100 mM NaCl, 1 mM EDTA, 35% Glycerol
Reconstitution Instructions:
Amino acid sequence: aa 2-285
Handling: Centrifuge the vial prior to opening.
Usage: For Research Use Only! Not to be used in humans
