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Product Description
Activin A Receptor Type 1B (ACVR1B, also known as ALK4) is a transmembrane serine/threonine kinase that complexes with type-2 activin receptors to transduce activin signaling. Activin signaling is responsible for regulating many physiological and pathological processes including neuronal differentiation and survival, hair follicle development, wound healing, extracellular matrix production, immunosuppression, and carcinogenesis. Mutations in ACVR1B are associated with pituitary tumors and pancreatic cancer.
Biovision | P1733 | Human CellExp™ ALK4 / ACVR1B (Active), Human Recombinant DataSheet
Biomolecule/Target :
Synonyms: Activin A Receptor Type 1B; SKR2; ACVRLK4; ACTR-IB; ACTRIB; ALK-4
Alternates names: Activin A Receptor Type 1B; SKR2; ACVRLK4; ACTR-IB; ACTRIB; ALK-4
Taglines: Activin receptor that is associated with pituitary tumors and pancreatic cancer
NCBI Gene ID #: 91
NCBI Gene Symbol:
Gene Source: Human
Accession #: P36896
Recombinant: True
Source: Human Cells
Purity by SDS-PAGE: > 95% by SDS-PAGE
Assay:
Purity:
Assay #2:
Endotoxin Level: < 1.0 EU per ug as determined by the LAL method
Activity (Specifications/test method): Immobilized Human TDGF1-Fc at 10 ug/ml (100 ul/well) can bind Human ACVR1B-His. The ED50 of Human ACVR1B-His is 4.7 ug/ml
Biological activity:
Results:
Binding Capacity:
Unit Definition:
Molecular Weight: 12.5 kDa calculated; 18 kDa observed
Concentration:
Appearance: Lyophilized protein
Physical form description: Lyophilized powder
Reconstitution Instructions:
Amino acid sequence: Ser 24 to Glu 126 with C-terminal 6xHis Tag
Handling: Centrifuge the vial prior to opening.
Usage: For Research Use Only! Not to be used in humans
