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Product Description
Human Programmed Cell Death 1 Ligand-1 (PD-L1) is also known as CD274 and B7-H1) is a type I transmembrane protein which binds to its receptor, Programmed Cell Death protein 1 (PD-1). PD-L1 is widely distributed on leukocytes, nonhematopoietic cells, and in nonlymphoid tissues including islets. PD-L1 and PD-1 pathway serves as an “immune checkpoint” and its blockade is a highly promising therapy for a broad spectrum of cancers.
Biovision | P1422 | Human CellExp™ Biotinylated PD-L1, Human Recombinant DataSheet
Biomolecule/Target :
Synonyms: Programmed Cell Death 1 Ligand 1, PDL1, PDCD1L1, CD274, B7 homolog 1, B7H1, B7-H1
Alternates names: Programmed Cell Death 1 Ligand 1, PDL1, PDCD1L1, CD274, B7 homolog 1, B7H1, B7-H1
Taglines:
NCBI Gene ID #: 29126
NCBI Gene Symbol: CD274
Gene Source: Human
Accession #: Q9NZQ7
Recombinant: False
Source: HEK293 cells
Purity by SDS-PAGE: ≥95%
Assay: SDS-PAGE
Purity:
Assay #2:
Endotoxin Level:
Activity (Specifications/test method): BioVision’s Biotinylated Human Recombinant PD-L1 has been tested for its biotin content (2-3 biotins per PD-L1 as determined by K811-100) and ability to bind Human PD-1 (Cat. No. 7498) in a functional ELISA with a linear range of 2-125 ng (0.02–1.25 ug/ml)
Biological activity:
Results:
Binding Capacity: BioVision’s Biotinylated Human Recombinant PD-L1 has been tested for its biotin content (2-3 biotins per PD-L1 as determined by K811-100) and ability to bind Human PD-1 (Cat. No. 7498) in a functional ELISA with a linear range of 2-125 ng (0.02–1.25 ug/ml)
Unit Definition:
Molecular Weight: The protein is fused with 6×His tag at the N-terminus, has a calculated MW of 26.4 kDa. The protein migrates as 35 -40 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Concentration: 0.5 mg/ml
Appearance: Sterile Filtered colorless solution
Physical form description: Liquid
Reconstitution Instructions:
Amino acid sequence: Leu 25-Gln 167
Handling: Centrifuge the vial prior to opening.
Usage:
