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Product Description
CD177 is a glycosyl-phosphatidylinositol (GPI)-linked N-glycosylated cell surface glycoprotein. CD177 contains two UPAR/Ly6 domains. CD177 is highly expressed in normal bone marrow and weakly expressed in fetal liver. Neutrophil-specific CD177 is a heterophilic binding partner of PECAM-1 (platelet endothelial cell adhesion molecule-1). This interaction mediates neutrophil transmigration.
Biovision | P1604 | Human CellExp™ CD177 DataSheet
Biomolecule/Target :
Synonyms: HNA-2a, PRV-1, N B1, NB1 GP, NB1 glycoprotein, Polycythemia rubra vera protein 1, Human neutrophil alloantigen 2a
Alternates names: HNA-2a, PRV-1, N B1, NB1 GP, NB1 glycoprotein, Polycythemia rubra vera protein 1, Human neutrophil alloantigen 2a
Taglines: A glycosyl-phosphatidylinositol (GPI)-linked N-glycosylated cell surface glycoprotein
NCBI Gene ID #: 57126
NCBI Gene Symbol:
Gene Source: Human
Accession #: Q8N6Q3
Recombinant: TRUE
Source: HEK293 cells
Purity by SDS-PAGE: > 97% by SDS-PAGE
Assay:
Purity:
Assay #2:
Endotoxin Level: < 0.1 EU/ug of the protein as determined by LAL method
Activity (Specifications/test method):
Biological activity:
Results:
Binding Capacity:
Unit Definition:
Molecular Weight: Recombinant human CD177 protein migrates as a band at 90-100 kDa in SDS-PAGE
Concentration:
Appearance: Lyophilized protein
Physical form description: Lyophilized protein
Reconstitution Instructions: Reconstitute to a concentration of 0.1-0.5 mg/ml in sterile distilled water
Amino acid sequence: The target protein is expressed with the sequence (Met1-Gly407) of human CD177 (Accession #NP_065139.2.) fused with a Fc, 6×His tag at the C-terminus
Handling: Centrifuge the vial prior to opening.
Usage: For Research Use Only! Not to be used in humans
