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Product Description
CD Antigen CD27 is also known as Tumor necrosis factor receptor superfamily member 7 (TNFRSF7), which belongs to TNF-receptor superfamily. CD27 / TNFRSF7 is found in most T-lymphocytes. CD27 / TNFRSF7 is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-κB and MAPK8/JNK. CD27 has been shown to interact with SIVA1, TRAF2 and TRAF3.
Biovision | P1406 | Human CellExp™ CD27 / TNFRSF7, Fc Tag, Mouse Recombinant DataSheet
Biomolecule/Target :
Synonyms: CD27, TNFRSF7, S152, T14, Tp55
Alternates names: CD27, TNFRSF7, S152, T14, Tp55
Taglines: Member of Tumor necrosis factor receptor superfamily, play a role in survival of activated T-cells and in apoptosis through association with SIVA1.
NCBI Gene ID #: 21940
NCBI Gene Symbol: Cd27
Gene Source: Murine
Accession #: P41272-1
Recombinant: True
Source: HEK 293 cells
Purity by SDS-PAGE: >95%
Assay: SDS-PAGE
Purity:
Assay #2:
Endotoxin Level: Less than 0.1 EU per ug by the LAL method
Activity (Specifications/test method): Immobilized Mouse CD27, Mouse IgG2a Fc Tag at 2 ug/mL (100 uL/well) can bind Biotinylated Mouse CD70, His Tag, Avi Tag with a linear range of 1-16 ng/m. Immobilized Mouse CD27, Mouse IgG2a Fc Tag at 2 ug/mL (100 uL/well) can bind Biotinylated Human CD27 Ligand, Fc Tag with a linear range of 1-16 ng/mL
Biological activity:
Results:
Binding Capacity: Immobilized Mouse CD27, Mouse IgG2a Fc Tag at 2 ug/mL (100 uL/well) can bind Biotinylated Mouse CD70, His Tag, Avi Tag with a linear range of 1-16 ng/m. Immobilized Mouse CD27, Mouse IgG2a Fc Tag at 2 ug/mL (100 uL/well) can bind Biotinylated Human CD27 Ligand, Fc Tag with a linear range of 1-16 ng/mL
Unit Definition:
Molecular Weight: This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 45.1 kDa. The protein migrates as 55-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation
Concentration:
Appearance: Lyophilized powder
Physical form description: Lyophilized
Reconstitution Instructions: Reconstitute in sterile deionized water to the desired protein concentration.
Amino acid sequence:
Handling: Centrifuge the vial prior to opening.
Usage:
