Euro
USD
British Pound
NULL
Product Description
DNAX accessory molecule 1 (DNAM-1), a single-pass type I membrane protein, is also known as CD226 antigen and platelet and T cell activation antigen 1 (PTA1), which contains 2 Ig-like C2-type (immunoglobulin-like) domains. DNAM-1 is a ~65 kDa glycoprotein expressed on the surface of natural killer cells, platelets, monocytes and a subset of T cells. DNAM-1 mediates cellular adhesion to other cells bearing its ligands, CD112 and CD155, and cross-linking DNAM-1 with antibodies causes cellular activation. Furthermore, DNAM-1 can interact with PVR and PVRL2.
Biovision | P1494 | Human CellExp™ DNAM-1 / CD226, Fc Tag, Human Recombinant DataSheet
Biomolecule/Target :
Synonyms: DNAM1, CD226, PTA1
Alternates names: DNAM1, CD226, PTA1
Taglines: Mediates cellular adhesion of platelets and megakaryocytic cells to vascular endothelial cells
NCBI Gene ID #: 10666
NCBI Gene Symbol: CD226
Gene Source: Human
Accession #: NP_006557
Recombinant: True
Source: HEK 293 cells
Purity by SDS-PAGE: >95%
Assay: SDS-PAGE
Purity:
Assay #2:
Endotoxin Level: Less than 1.0 EU per ug by the LAL method.
Activity (Specifications/test method): Immobilized Rhesus macaque CD155 at 5 ug/mL (100 uL/well) can bind Human DNAM-1, Fc Tag with a linear range of 2-31 ng/mL
Biological activity:
Results:
Binding Capacity:
Unit Definition:
Molecular Weight: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 52.6 kDa. The protein migrates as 66-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Concentration:
Appearance: Lyophilized powder
Physical form description: Lyophilized
Reconstitution Instructions: Reconstitute in sterile deionized water to the desired protein concentration.
Amino acid sequence: AA Glu 19 - Asn 247
Handling: Centrifuge the vial prior to opening.
Usage: For Research Use Only! Not to be used in humans
