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Product Description
Ephrin-A1 (EFNA1) is a membrane-anchored ligend that binds to ephrin Type-A receptors such as EphA2 and EphA7. EFNA1 plays a key role in angiogenesis in normal and tumor contexts through its interaction with EphA2, which leads to Rac1 GTPase activation and subsequent vascular endothelial cell migration. While it has anti-oncogenic effects through its downregulation of EphA2 and FAK, EFNA1 overexpression has been observed in gastric cancer.
Biovision | P1728 | Human CellExp™ Ephrin-A1 / EFNA1 (Active), Human Recombinant DataSheet
Biomolecule/Target :
Synonyms: Ephrin A1; LERK1; EFL1; B61; EPH-Related Receptor Tyrosine Kinase Ligand 1; TNF Alpha-Induced Protein 4; TNFAIP4; ECKLG; EPLG1; GMAN;
Alternates names: Ephrin A1; LERK1; EFL1; B61; EPH-Related Receptor Tyrosine Kinase Ligand 1; TNF Alpha-Induced Protein 4; TNFAIP4; ECKLG; EPLG1; GMAN;
Taglines: Plays an important role in angiogenesis
NCBI Gene ID #: 1942
NCBI Gene Symbol:
Gene Source: Human
Accession #: P20827
Recombinant: True
Source: Human Cells
Purity by SDS-PAGE: > 95% by SDS-PAGE
Assay:
Purity:
Assay #2:
Endotoxin Level: < 1.0 EU per ug as determined by the LAL method
Activity (Specifications/test method): Immobilized Human Ephrin-A1-His at 10 ug/ml (100 ul/well) can bind Human EphA2-Fc. The ED50 of Human Ephrin-A1-His is 12.43 ug/ml
Biological activity:
Results:
Binding Capacity:
Unit Definition:
Molecular Weight: 20.4 kDa predicted, 24-28 kDa observed
Concentration:
Appearance: Lyophilized protein
Physical form description: Lyophilized powder
Reconstitution Instructions:
Amino acid sequence: Asp 19 to Ser 182 with C-terminal 6xHis Tag
Handling: Centrifuge the vial prior to opening.
Usage: For Research Use Only! Not to be used in humans
