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Product Description
FcgR4 (Low affinity immunoglobulin gamma Fc region receptor IV) is also known as CD16-2, FcgammaRIV, receptor for the Fc region of immunoglobulin gamma. Also acts as a receptor for the Fc region of immunoglobulin epsilon. Binds with intermediate affinity to both IgG2a and IgG2b. Does not display binding to IgG1 or IgG3. Plays a role in promoting bone resorption by enhancing osteoclast differentiation following binding to IgG2a. Binds with low affinity to both the a and b allotypes of IgE. Has also been shown to bind to IgE allotype a only but not to allotype b. Binding to IgE promotes macrophage-mediated phagocytosis, antigen presentation to T cells, production of proinflammatory cytokines and the late phase of cutaneous allergic reactions.
Biovision | P1426 | Human CellExp™ Fc gamma RIV / CD16-2, Mouse recombinant DataSheet
Biomolecule/Target :
Synonyms: Fc gamma RIV, CD16-2, Fcgr4
Alternates names: Fc gamma RIV, CD16-2, Fcgr4
Taglines: Plays a role in promoting bone resorption by enhancing osteoclast differentiation following binding to IgG2a.
NCBI Gene ID #: 246256
NCBI Gene Symbol: Fcgr4
Gene Source: Mouse
Accession #: A0A0B4J1G0
Recombinant: True
Source: HEK 293 Cells
Purity by SDS-PAGE: >90%
Assay: SDS-PAGE
Purity:
Assay #2:
Endotoxin Level: Less than 1.0 EU per ug by the LAL method.
Activity (Specifications/test method):
Biological activity:
Results:
Binding Capacity:
Unit Definition:
Molecular Weight: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 22.8 kDa. The protein migrates as 28-35 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Concentration:
Appearance: Lyophilized powder
Physical form description: Lyophilized powder
Reconstitution Instructions: Reconstitute in sterile deionized water to the desired protein concentration.
Amino acid sequence: AA Gly 21 - Gln 203
Handling: Centrifuge the vial prior to opening.
Usage:
