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Product Description
Flt-3(Receptor-type tyrosine-protein kinase FLT3) is also known as FLK-2(Fetal liver kinase-2), STK-1(Stem cell tyrosine kinase 1), CD135. FLT3 is a cytokine receptor which belongs to the receptor tyrosine kinase class III. Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways.
Biovision | P1459 | Human CellExp™Flt-3 / Flk-2, Fc Tag, Human Recombinant DataSheet
Biomolecule/Target :
Synonyms: Flt-3, Flk-2, STK-1, CD135, FLK2, FLT-3
Alternates names: Flt-3, Flk-2, STK-1, CD135, FLK2, FLT-3
Taglines: A member of a small family of growth factors that stimulate the proliferation of hematopoietic cells
NCBI Gene ID #: 2323
NCBI Gene Symbol: FLT3LG
Gene Source: Human
Accession #: P36888-1
Recombinant: True
Source: HEK 293 cells
Purity by SDS-PAGE: >95%
Assay: SDS-PAGE
Purity:
Assay #2:
Endotoxin Level: Less than 1.0 EU per ug by the LAL method.
Activity (Specifications/test method):
Biological activity:
Results:
Binding Capacity:
Unit Definition:
Molecular Weight: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 84.8 kDa. The protein migrates as 110-120 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Concentration:
Appearance: Lyophilized protein
Physical form description: Lyophilized
Reconstitution Instructions: Reconstitute in sterile deionized water to the desired protein concentration.
Amino acid sequence: Asn 27 - Ser 543
Handling: Centrifuge the vial prior to opening.
Usage:
