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Product Description
Frizzled-2 (FZD2) is also known as FzE2, which belongs to the G-protein coupled receptor Fz/Smo family. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. FZD2 contains one FZ (frizzled) domain. FZD2 may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. The Lys-Thr-X-X-X-Trp motif of FZD2 interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.
Biovision | P1026 | Human CellExp™ Frizzled-2 / FZD2 Protein, Human recombinant DataSheet
Biomolecule/Target :FZD2
Synonyms: FZD2, Frizzled-2, Fz-2, hFz2, FzE2
Alternates names: FZD2, Frizzled-2, Fz-2, hFz2, FzE2
Taglines:
NCBI Gene ID #: 2535
NCBI Gene Symbol: FZD2
Gene Source: Human
Accession #: Q14332
Recombinant: Yes
Source: HEK 293 cells
Purity by SDS-PAGE: > 95%
Assay: SDS-PAGE
Purity: N/A
Assay #2: N/A
Endotoxin Level: N/A
Activity (Specifications/test method): N/A
Biological activity: N/A
Results: N/A
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: 41.7 kDa
Concentration: N/A
Appearance: Lyophilized
Physical form description: Lyophilized from 0.22 um filtered solution in 50 mM tris, 100 mM glycine, pH 7.5.
Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 ug/ml. Do not vortex.
Amino acid sequence: N/A
Handling: Centrifuge the vial prior to opening.
Usage: For Research Use Only! Not to be used in humans
