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Product Description
ICOS ligand (ICOSLG) is also known as B7 homolog 2 (B7-H2), B7-related protein 1 (B7RP-1) and CD antigen CD275, which belongs to the immunoglobulin superfamily and BTN/MOG family. ICOSLG contains one Ig-like C2-type (immunoglobulin-like) domain and one Ig-like V-type (immunoglobulin-like) domain. Isoform 1 is widely expressed, while isoform 2 is detected only in lymph nodes, leukocytes and spleen. B7-H2 is ligand for the T-cell-specific cell surface receptor ICOS. B7-H2 acts as a costimulatory signal for T-cell proliferation and cytokine secretion and induces also B-cell proliferation and differentiation into plasma cells. B7-H2 could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function.
Biovision | P1478 | Human CellExp™ ICOSLG /B7-H2 /CD275, Mouse Recombinant DataSheet
Biomolecule/Target :
Synonyms: ICOSLG, B7-H2, B7H2, B7RP-1, B7RP1, CD275, GL50, ICOS-L, ICOSL, LICOS, ICOS ligand
Alternates names: ICOSLG, B7-H2, B7H2, B7RP-1, B7RP1, CD275, GL50, ICOS-L, ICOSL, LICOS, ICOS ligand
Taglines: Ligand for the T-cell-specific cell surface receptor ICOS
NCBI Gene ID #: 50723
NCBI Gene Symbol: ICOSLG
Gene Source: Mouse
Accession #: Q9JHJ8-1
Recombinant: True
Source: HEK 293 cells
Purity by SDS-PAGE: >90%
Assay: SDS-PAGE
Purity:
Assay #2:
Endotoxin Level: Less than 1.0 EU per ug by the LAL method.
Activity (Specifications/test method): Immobilized Mouse B7-H2, His Tag at 1 ug/mL (100 uL/well) can bind Mouse ICOS, Fc Tag with a linear range of 1-78 ng/mL
Biological activity:
Results:
Binding Capacity:
Unit Definition:
Molecular Weight: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 28.2 kDa. The protein migrates as 45-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Concentration:
Appearance: Lyophilized powder
Physical form description: Lyophilized powder
Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in sterile deionized water to a concentration of 100 ug/ml. Do not vortex. It is recommended to store at -20°C.
Amino acid sequence: Glu 47 - Lys 279
Handling: Centrifuge the vial prior to opening.
Usage: For Research Use Only! Not to be used in humans
