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Product Description
IL15R is a heterotrimer of IL15RA, IL2RB and IL2RG. IL-15RA, also known as CD215, IL-15 R alpha, is a widely expressed 60 kDa transmembrane glycoprotein. High-affinity receptor for interleukin-15. Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Expression of different isoforms may alter or interfere with signal transduction. An interleukin (IL)-15 superagonist/IL-15 receptor α fusion complex (IL-15SA/IL-15RA; ALT-803) activates the IL-15 receptor on CD8 T cells and NK cells, and has shown significant anti-tumor. Signal transduction involves SYK. Higher levels of soluble sIL-15RA form in comparison with membrane-bound forms is present in all brain structures.
Biovision | P1424 | Human CellExp™ IL-15 R alpha / CD215, Fc Tag, Human recombinant DataSheet
Biomolecule/Target :
Synonyms: IL15RA, IL-15RA, IL-15R-alpha, IL-15 receptor subunit alpha
Alternates names: IL15RA, IL-15RA, IL-15R-alpha, IL-15 receptor subunit alpha
Taglines: High-affinity receptor for interleukin-15.
NCBI Gene ID #: Q13261
NCBI Gene Symbol: IL15RA
Gene Source: Human
Accession #: Q13261
Recombinant: False
Source: HEK 293 Cells
Purity by SDS-PAGE: >95%
Assay: SDS-PAGE
Purity:
Assay #2:
Endotoxin Level: Less than 1.0 EU per ug by the LAL method.
Activity (Specifications/test method): Immobilized Human IL-15 R alpha, Fc Tag at 2 ug/ml (100 ul/well) can bind Biotinylated Human IL-15 with a linear range of 2-78 ng/ml.
Biological activity:
Results:
Binding Capacity:
Unit Definition:
Molecular Weight: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 44.8 kDa. The protein migrates as 60-80 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Concentration:
Appearance: Lyophilized powder
Physical form description: Lyophilized powder
Reconstitution Instructions: Reconstitute in sterile deionized water to the desired protein concentration.
Amino acid sequence: AA Ile 31 - Thr 205
Handling: Centrifuge the vial prior to opening.
Usage:
